PCA9546A: Asking fro the PCA9546 setting and the leakage questiosn

Part Number:PCA9546A

Hi team,

Could you please help for the quesitons?
1. Are they ok to pull SDA/SCL to 3.3V and SD0/SD1 pull high to 5V?
2. cusotmer's sclar uses PCA9546 to read/write the DDC EEPROM. If the PCA9546 did not has VCC powerand the SD0/SC0 was pulled high to 5V for external PC read DDC EEPROM, will SDA/SCL has the leakage voltage from SD0/SC0 5V?
3. If Channel 0~3 are set as disable, will that have the impact on DDC EEPROM read/write by external PC?

Here is the block diagram

Thanks,

SHH