CC2652R: Correct recommendation for VDDS2 and VDDS3

Part Number: CC2652R

Hello team,

Hope you are doing well. Please see below customer question

1. We are working with CC2652R under the assumption that we can perform BLE functions in parallel with some fairly intensive number crunching. Is this accurate?
2. The CC2652R is connected to 3.3V peripherals that will need to be powered down most of the time.  Ideally, we would like to power down the I/O of the CC2652R in order to keep software simpler and power that much lower.  The CC2652R has I/O power supply pins, and specifies well what is powered by which and the range of voltages allowed.  However, it also says “(3) VDDS_DCDC, VDDS2 and VDDS3 must be at the same potential as VDDS.”  So the question becomes, which is correct – can we run VDDS2 and VDDS3 at a different voltage to accommodate specific I/O needs?  Can we power down VDDS2 and VDDS3 while VDDS keeps running?  The idea of an I/O voltage suggests we could, but the note in the AMR chart suggests we cannot.